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A Phase II Randomized Trial to Explore the Potential for Pharmacokinetic Drug–Drug Interactions with Stiripentol or Valproate when Combined with Cannabidiol in Patients with Epilepsy

BACKGROUND: In recent randomized, placebo-controlled, phase III trials, highly purified cannabidiol demonstrated efficacy with an acceptable safety profile in patients with Lennox–Gastaut syndrome or Dravet syndrome. It is anticipated that antiepileptic drugs such as stiripentol and valproate will b...

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Bibliografiske detaljer
Udgivet i:CNS Drugs
Main Authors: Ben-Menachem, Elinor, Gunning, Boudewijn, Arenas Cabrera, Carmen María, VanLandingham, Kevan, Crockett, Julie, Critchley, David, Wray, Louise, Tayo, Bola, Morrison, Gilmour, Toledo, Manuel
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7275018/
https://ncbi.nlm.nih.gov/pubmed/32350749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40263-020-00726-4
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