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Relaxation of Extracellular Matrix Forces Directs Crypt Formation and Architecture in Intestinal Organoids

Intestinal organoid protocols rely on the use of extracellular scaffolds, typically Matrigel, and upon switching from growth to differentiation promoting media, a symmetry breaking event takes place. During this stage, the first bud like structures analogous to crypts protrude from the central body...

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Detalhes bibliográficos
Publicado no:Adv Healthc Mater
Main Authors: Hushka, Ella A., Yavitt, F. Max, Brown, Tobin E., Dempsey, Peter J., Anseth, Kristi S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7274865/
https://ncbi.nlm.nih.gov/pubmed/31957249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adhm.201901214
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