Cryo-EM structure of NPF-bound human Arp2/3 complex and activation mechanism

Actin-related protein (Arp) 2/3 complex nucleates branched actin networks that drive cell motility. It consists of seven proteins, including two actin-related subunits (Arp2 and Arp3). Two nucleation-promoting factors (NPFs) bind Arp2/3 complex during activation, but the order, specific interactions...

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Bibliographic Details
Published in:Sci Adv
Main Authors: Zimmet, Austin, Van Eeuwen, Trevor, Boczkowska, Malgorzata, Rebowski, Grzegorz, Murakami, Kenji, Dominguez, Roberto
Format: Artigo
Language:Inglês
Published: American Association for the Advancement of Science 2020
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7274804/
https://ncbi.nlm.nih.gov/pubmed/32917641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz7651
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