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Cryo-EM structure of NPF-bound human Arp2/3 complex and activation mechanism
Actin-related protein (Arp) 2/3 complex nucleates branched actin networks that drive cell motility. It consists of seven proteins, including two actin-related subunits (Arp2 and Arp3). Two nucleation-promoting factors (NPFs) bind Arp2/3 complex during activation, but the order, specific interactions...
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| Publicado no: | Sci Adv |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7274804/ https://ncbi.nlm.nih.gov/pubmed/32917641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz7651 |
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