Topological control of cytokine receptor signaling induces differential effects in hematopoiesis

INTRODUCTION: Receptor dimerization is a fundamental mechanism by which most cytokines and growth factors activate Type-I transmembrane receptors. Although previous studies have shown that ligand-induced topological changes in the extracellular domains (ECDs) of dimeric receptors can affect signalin...

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Vydáno v:Science
Hlavní autoři: Mohan, Kritika, Ueda, George, Kim, Ah Ram, Jude, Kevin M., Fallas, Jorge A., Guo, Yu, Hafer, Maximillian, Miao, Yi, Saxton, Robert A., Piehler, Jacob, Sankaran, Vijay G., Baker, David, Garcia, K. Christopher
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7274355/
https://ncbi.nlm.nih.gov/pubmed/31123111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav7532
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