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Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
INTRODUCTION: Receptor dimerization is a fundamental mechanism by which most cytokines and growth factors activate Type-I transmembrane receptors. Although previous studies have shown that ligand-induced topological changes in the extracellular domains (ECDs) of dimeric receptors can affect signalin...
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| Izdano u: | Science |
|---|---|
| Glavni autori: | , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7274355/ https://ncbi.nlm.nih.gov/pubmed/31123111 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav7532 |
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