A co-formulation of supramolecularly stabilized insulin and pramlintide enhances meal-time glucagon suppression in diabetic pigs

In diabetic patients, treatment with insulin and pramlintide (an amylin analogue) is more effective than treatment with insulin only. But because mixtures of insulin and pramlintide are unstable and have to be injected separately, amylin analogues are only used by 1.5% of diabetics needing rapid-act...

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Publicat a:Nat Biomed Eng
Autors principals: Maikawa, Caitlin L., Smith, Anton A. A., Zou, Lei, Roth, Gillie A., Gale, Emily C., Stapleton, Lyndsay M., Baker, Sam W., Mann, Joseph L., Yu, Anthony C., Correa, Santiago, Grosskopf, Abigail K., Liong, Celine S., Meis, Catherine M., Chan, Doreen, Troxell, Megan, Maahs, David M., Buckingham, Bruce A., Webber, Matthew J., Appel, Eric A.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7274092/
https://ncbi.nlm.nih.gov/pubmed/32393892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-020-0555-4
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