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Rats are protected from the stress of chronic pressure overload compared with mice

The goal of this investigation was to compare the effects of chronic (4 wk) transverse aortic constriction (TAC) in Sprague-Dawley rats and C57BL/6J mice. TAC, after 1 day, induced similar left ventricular (LV) pressure gradients in both rats (n = 7) and mice (n = 7) (113 ± 5.4 vs. 103 ± 11.5 mmHg),...

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Veröffentlicht in:Am J Physiol Regul Integr Comp Physiol
Hauptverfasser: Nishimura, Koichi, Oydanich, Marko, Zhang, Jie, Babici, Denis, Fraidenraich, Diego, Vatner, Dorothy E., Vatner, Stephen F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272766/
https://ncbi.nlm.nih.gov/pubmed/32209023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00370.2019
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