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Stat3 activation induces insulin resistance via a muscle-specific E3 ubiquitin ligase Fbxo40
Cellular mechanisms causing insulin resistance (IR) in chronic kidney disease (CKD) are poorly understood. One potential mechanism is that CKD-induced inflammation activates the signal transducer and activator of transcription 3 (Stat3) in muscle. We uncovered increased p-Stat3 in muscles of mice wi...
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| Publicado no: | Am J Physiol Endocrinol Metab |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7272729/ https://ncbi.nlm.nih.gov/pubmed/32101031 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00480.2019 |
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