Inhibition of Stat3 Activation Suppresses Caspase-3 and the Ubiquitin-Proteasome System, Leading to Preservation of Muscle Mass in Cancer Cachexia

Cachexia occurs in patients with advanced cancers. Despite the adverse clinical impact of cancer-induced muscle wasting, pathways causing cachexia are controversial, and clinically reliable therapies are not available. A trigger of muscle protein loss is the Jak/Stat pathway, and indeed, we found th...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Silva, Kleiton Augusto Santos, Dong, Jiangling, Dong, Yanjun, Dong, Yanlan, Schor, Nestor, Tweardy, David J., Zhang, Liping, Mitch, William E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409274/
https://ncbi.nlm.nih.gov/pubmed/25787076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.641514
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