Hypoxia-induced shift in the phenotype of proteasome from 26S toward immunoproteasome triggers loss of immunoprivilege of mesenchymal stem cells

Allogeneic mesenchymal stem cells (MSCs) are immunoprivileged and are being investigated in phase I and phase II clinical trials to treat different degenerative and autoimmune diseases. In spite of encouraging outcome of initial trials, the long-term poor survival of transplanted cells in the host t...

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Publicado no:Cell Death Dis
Main Authors: Abu-El-Rub, Ejlal, Sareen, Niketa, Yan, Weiang, Alagarsamy, Keshav Narayan, Rafieerad, Alireza, Srivastava, Abhay, Desiderio, Vincenzo, Dhingra, Sanjiv
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272449/
https://ncbi.nlm.nih.gov/pubmed/32499535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2634-6
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