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Hypoxia-induced 26S proteasome dysfunction increases immunogenicity of mesenchymal stem cells

Bone marrow-derived allogeneic (donor derived) mesenchymal stem cells (MSCs) are immunoprivileged and are considered to be prominent candidates for regenerative therapy for numerous degenerative diseases. Even though the outcome of initial allogeneic MSCs based clinical trials was encouraging, the o...

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Détails bibliographiques
Publié dans:Cell Death Dis
Auteurs principaux: Abu-El-Rub, Ejlal, Sequiera, Glen Lester, Sareen, Niketa, Yan, Weiang, Moudgil, Meenal, Sabbir, Mohammad Golam, Dhingra, Sanjiv
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6349874/
https://ncbi.nlm.nih.gov/pubmed/30692516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1359-x
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