Hypoxia-induced shift in the phenotype of proteasome from 26S toward immunoproteasome triggers loss of immunoprivilege of mesenchymal stem cells

Allogeneic mesenchymal stem cells (MSCs) are immunoprivileged and are being investigated in phase I and phase II clinical trials to treat different degenerative and autoimmune diseases. In spite of encouraging outcome of initial trials, the long-term poor survival of transplanted cells in the host t...

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Vydáno v:Cell Death Dis
Hlavní autoři: Abu-El-Rub, Ejlal, Sareen, Niketa, Yan, Weiang, Alagarsamy, Keshav Narayan, Rafieerad, Alireza, Srivastava, Abhay, Desiderio, Vincenzo, Dhingra, Sanjiv
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272449/
https://ncbi.nlm.nih.gov/pubmed/32499535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2634-6
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