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Neural tube development depends on notochord-derived sonic hedgehog released into the sclerotome

Sonic hedgehog (Shh), produced in the notochord and floor plate, is necessary for both neural and mesodermal development. To reach the myotome, Shh has to traverse the sclerotome and a reduction of sclerotomal Shh affects myotome differentiation. By investigating loss and gain of Shh function, and f...

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Publicat a:Development
Autors principals: Kahane, Nitza, Kalcheim, Chaya
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists Ltd 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272346/
https://ncbi.nlm.nih.gov/pubmed/32345743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.183996
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