Evaluating drug targets through human loss-of-function genetic variation

Naturally occurring human genetic variants that are predicted to inactivate protein-coding genes provide an in vivo model of human gene inactivation that complements knockout studies in cells and model organisms. Here we report three key findings regarding the assessment of candidate drug targets us...

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Dades bibliogràfiques
Publicat a:Nature
Autors principals: Minikel, Eric Vallabh, Karczewski, Konrad J., Martin, Hilary C., Cummings, Beryl B., Whiffin, Nicola, Rhodes, Daniel, Alföldi, Jessica, Trembath, Richard C., van Heel, David A., Daly, Mark J., Schreiber, Stuart L., MacArthur, Daniel G.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Analysis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272226/
https://ncbi.nlm.nih.gov/pubmed/32461653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2267-z
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