Using high-resolution variant frequencies to empower clinical genome interpretation

PURPOSE: Whole-exome and whole-genome sequencing have transformed the discovery of genetic variants that cause human Mendelian disease, but discriminating pathogenic from benign variants remains a daunting challenge. Rarity is recognized as a necessary, although not sufficient, criterion for pathoge...

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Detalhes bibliográficos
Publicado no:Genet Med
Main Authors: Whiffin, Nicola, Minikel, Eric, Walsh, Roddy, O’Donnell-Luria, Anne H, Karczewski, Konrad, Ing, Alexander Y, Barton, Paul J R, Funke, Birgit, Cook, Stuart A, MacArthur, Daniel, Ware, James S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563454/
https://ncbi.nlm.nih.gov/pubmed/28518168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gim.2017.26
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