T1D progression is associated with loss of CD3(+)CD56(+) regulatory T cells that control CD8(+) T cell effector functions

An unresolved issue in autoimmunity is the lack of surrogate biomarkers of immunological self-tolerance for disease monitoring. Here, we show that peripheral frequency of a regulatory T cell population, characterized by the co-expression of CD3 and CD56 molecules (T(R3-56)), is reduced in subjects w...

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Detalhes bibliográficos
Publicado no:Nat Metab
Main Authors: Terrazzano, Giuseppe, Bruzzaniti, Sara, Rubino, Valentina, Santopaolo, Marianna, Palatucci, Anna Teresa, Giovazzino, Angela, La Rocca, Claudia, de Candia, Paola, Puca, Annibale, Perna, Francesco, Procaccini, Claudio, De Rosa, Veronica, Porcellini, Chiara, De Simone, Salvatore, Fattorusso, Valentina, Porcellini, Antonio, Mozzillo, Enza, Troncone, Riccardo, Franzese, Adriana, Ludvigsson, Johnny, Matarese, Giuseppe, Ruggiero, Giuseppina, Galgani, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272221/
https://ncbi.nlm.nih.gov/pubmed/32500117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-020-0173-1
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