Bridging integrator 1 protein loss in Alzheimer’s disease promotes synaptic tau accumulation and disrupts tau release

Polymorphisms associated with BIN1 (bridging integrator 1) confer the second greatest risk for developing late-onset Alzheimer’s disease. The biological consequences of this genetic variation are not fully understood; however, BIN1 is a binding partner for tau. Tau is normally a highly soluble cytop...

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Publicado en:Brain Commun
Autores principales: Glennon, Elizabeth B, Lau, Dawn H W, Gabriele, Rebecca M C, Taylor, Matthew F, Troakes, Claire, Opie-Martin, Sarah, Elliott, Christina, Killick, Richard, Hanger, Diane P, Perez-Nievas, Beatriz G, Noble, Wendy
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272218/
https://ncbi.nlm.nih.gov/pubmed/32500121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/braincomms/fcaa011
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