Amino and PEG-Amino Graphene Oxide Grids Enrich and Protect Samples for High-resolution Single Particle Cryo-electron Microscopy

Cryo-EM samples prepared using traditional methods often suffer from too few particles, poor particle distribution, strongly biased orientation, or damage from the air-water interface. Here we report that functionalization of graphene oxide (GO) coated grids with amino groups concentrates samples on...

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Veröffentlicht in:J Struct Biol
Hauptverfasser: Wang, Feng, Yu, Zanlin, Betegon, Miguel, Campbell, Melody G., Aksel, Tural, Zhao, Jianhua, Li, Sam, Douglas, Shawn M., Cheng, Yifan, Agard, David A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7272056/
https://ncbi.nlm.nih.gov/pubmed/31866389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2019.107437
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