Human laminin-111 and laminin-211 protein therapy prevents muscle disease progression in an immunodeficient mouse model of LAMA2-CMD

BACKGROUND: Laminin-α2-related congenital muscular dystrophy (LAMA2-CMD) is a devastating genetic disease caused by mutations in the LAMA2 gene. These mutations result in progressive muscle wasting and inflammation leading to delayed milestones, and reduced lifespan in affected patients. There is cu...

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Enregistré dans:
Détails bibliographiques
Publié dans:Skelet Muscle
Auteurs principaux: Barraza-Flores, Pamela, Hermann, Hailey J., Bates, Christina R., Allen, Tyler G., Grunert, Timothy T., Burkin, Dean J.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2020
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7271547/
https://ncbi.nlm.nih.gov/pubmed/32498713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13395-020-00235-4
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