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Metabolic energy sensing by mammalian CLC anion/proton exchangers

CLC anion/proton exchangers control the pH and [Cl(−)] of the endolysosomal system that is essential for cellular nutrient uptake. Here, we use heterologous expression and whole‐cell electrophysiology to investigate the regulation of the CLC isoforms ClC‐3, ClC‐4, and ClC‐5 by the adenylic system co...

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Detalles Bibliográficos
Publicado en:EMBO Rep
Main Authors: Grieschat, Matthias, Guzman, Raul E, Langschwager, Katharina, Fahlke, Christoph, Alekov, Alexi K
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7271328/
https://ncbi.nlm.nih.gov/pubmed/32390228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201947872
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