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Metabolic energy sensing by mammalian CLC anion/proton exchangers

CLC anion/proton exchangers control the pH and [Cl(−)] of the endolysosomal system that is essential for cellular nutrient uptake. Here, we use heterologous expression and whole‐cell electrophysiology to investigate the regulation of the CLC isoforms ClC‐3, ClC‐4, and ClC‐5 by the adenylic system co...

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Bibliographic Details
Published in:EMBO Rep
Main Authors: Grieschat, Matthias, Guzman, Raul E, Langschwager, Katharina, Fahlke, Christoph, Alekov, Alexi K
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7271328/
https://ncbi.nlm.nih.gov/pubmed/32390228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201947872
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