Variability in Cardiac miRNA-122 Level Determines Therapeutic Potential of miRNA-Regulated AAV Vectors

Systemically delivered adeno-associated viral vector serotype 9 (AAV9) effectively transduces murine heart, but provides transgene expression also in liver and skeletal muscles. Improvement of the selectivity of transgene expression can be achieved through incorporation of target sites (TSs) for miR...

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Bibliographic Details
Published in:Mol Ther Methods Clin Dev
Main Authors: Kraszewska, Izabela, Tomczyk, Mateusz, Andrysiak, Kalina, Biniecka, Monika, Geisler, Anja, Fechner, Henry, Zembala, Michał, Stępniewski, Jacek, Dulak, Józef, Jaźwa-Kusior, Agnieszka
Format: Artigo
Language:Inglês
Published: American Society of Gene & Cell Therapy 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7270145/
https://ncbi.nlm.nih.gov/pubmed/32518806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.05.006
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