Variability in Cardiac miRNA-122 Level Determines Therapeutic Potential of miRNA-Regulated AAV Vectors

Systemically delivered adeno-associated viral vector serotype 9 (AAV9) effectively transduces murine heart, but provides transgene expression also in liver and skeletal muscles. Improvement of the selectivity of transgene expression can be achieved through incorporation of target sites (TSs) for miR...

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Bibliografiset tiedot
Julkaisussa:Mol Ther Methods Clin Dev
Päätekijät: Kraszewska, Izabela, Tomczyk, Mateusz, Andrysiak, Kalina, Biniecka, Monika, Geisler, Anja, Fechner, Henry, Zembala, Michał, Stępniewski, Jacek, Dulak, Józef, Jaźwa-Kusior, Agnieszka
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Gene & Cell Therapy 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7270145/
https://ncbi.nlm.nih.gov/pubmed/32518806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.05.006
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