Variability in Cardiac miRNA-122 Level Determines Therapeutic Potential of miRNA-Regulated AAV Vectors

Systemically delivered adeno-associated viral vector serotype 9 (AAV9) effectively transduces murine heart, but provides transgene expression also in liver and skeletal muscles. Improvement of the selectivity of transgene expression can be achieved through incorporation of target sites (TSs) for miR...

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Publicado en:Mol Ther Methods Clin Dev
Main Authors: Kraszewska, Izabela, Tomczyk, Mateusz, Andrysiak, Kalina, Biniecka, Monika, Geisler, Anja, Fechner, Henry, Zembala, Michał, Stępniewski, Jacek, Dulak, Józef, Jaźwa-Kusior, Agnieszka
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Gene & Cell Therapy 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7270145/
https://ncbi.nlm.nih.gov/pubmed/32518806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.05.006
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