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Astragalus polysaccharides reverse gefitinib resistance by inhibiting mesenchymal transformation in lung adenocarcinoma cells

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have been used as first-line recommended therapy for EGFR mutant non-small cell lung cancer patients. However, epithelial-mesenchymal transition (EMT) can reduce EGFR-TKI sensitivity and lead to resistance. This study was design...

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Bibliografiske detaljer
Udgivet i:Am J Transl Res
Main Authors: Wei, Jia, Li, Yanmeng, Xu, Bo, Yu, Jing
Format: Artigo
Sprog:Inglês
Udgivet: e-Century Publishing Corporation 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269999/
https://ncbi.nlm.nih.gov/pubmed/32509166
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