Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro

Inhibition of acid sphingomyelinase (ASM), a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin into ceramide and phosphorylcholine, may serve as an investigational tool or a therapeutic intervention to control many diseases. Specific ASM inhibitors are currently not sufficiently charac...

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Publicat a:J Lipid Res
Autors principals: Naser, Eyad, Kadow, Stephanie, Schumacher, Fabian, Mohamed, Zainelabdeen H., Kappe, Christian, Hessler, Gabriele, Pollmeier, Barbara, Kleuser, Burkhard, Arenz, Christoph, Becker, Katrin Anne, Gulbins, Erich, Carpinteiro, Alexander
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269768/
https://ncbi.nlm.nih.gov/pubmed/32156719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA120000682
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