Skin barrier lipid enzyme activity in Netherton patients is associated with protease activity and ceramide abnormalities

Individuals with Netherton syndrome (NTS) have increased serine protease activity, which strongly impacts the barrier function of the skin epidermis and leads to skin inflammation. Here, we investigated how serine protease activity in NTS correlates with changes in the stratum corneum (SC) ceramides...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: van Smeden, Jeroen, Al-Khakany, Hanin, Wang, Yichen, Visscher, Dani, Stephens, Nicole, Absalah, Samira, Overkleeft, Herman S., Aerts, Johannes M. F. G., Hovnanian, Alain, Bouwstra, Joke A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269766/
https://ncbi.nlm.nih.gov/pubmed/32265319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.RA120000639
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