In situ visualization of glucocerebrosidase in human skin tissue: zymography versus activity-based probe labeling

Epidermal β-glucocerebrosidase (GBA1), an acid β-glucosidase normally located in lysosomes, converts (glucosyl)ceramides into ceramides, which is crucial to generate an optimal barrier function of the outermost skin layer, the stratum corneum (SC). Here we report on two developed in situ methods to...

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Dettagli Bibliografici
Pubblicato in:J Lipid Res
Autori principali: van Smeden, Jeroen, Dijkhoff, Irini M., Helder, Richard W. J., Al-Khakany, Hanin, Boer, Daphne E. C., Schreuder, Anne, Kallemeijn, Wouter W., Absalah, Samira, Overkleeft, Herman S., Aerts, Johannes M. F. G., Bouwstra, Joke A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2017
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5711493/
https://ncbi.nlm.nih.gov/pubmed/29025868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M079376
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