In situ visualization of glucocerebrosidase in human skin tissue: zymography versus activity-based probe labeling

Epidermal β-glucocerebrosidase (GBA1), an acid β-glucosidase normally located in lysosomes, converts (glucosyl)ceramides into ceramides, which is crucial to generate an optimal barrier function of the outermost skin layer, the stratum corneum (SC). Here we report on two developed in situ methods to...

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Vydáno v:J Lipid Res
Hlavní autoři: van Smeden, Jeroen, Dijkhoff, Irini M., Helder, Richard W. J., Al-Khakany, Hanin, Boer, Daphne E. C., Schreuder, Anne, Kallemeijn, Wouter W., Absalah, Samira, Overkleeft, Herman S., Aerts, Johannes M. F. G., Bouwstra, Joke A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2017
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5711493/
https://ncbi.nlm.nih.gov/pubmed/29025868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M079376
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