Shortened TDP43 isoforms upregulated by neuronal hyperactivity drive TDP43 pathology in ALS

Cortical hyperexcitability and mislocalization of the RNA-binding protein TDP43 are highly conserved features in amyotrophic lateral sclerosis (ALS). Nevertheless, the relationship between these phenomena remains poorly defined. Here, we showed that hyperexcitability recapitulates TDP43 pathology by...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Weskamp, Kaitlin, Tank, Elizabeth M., Miguez, Roberto, McBride, Jonathon P., Gómez, Nicolás B., White, Matthew, Lin, Ziqiang, Gonzalez, Carmen Moreno, Serio, Andrea, Sreedharan, Jemeen, Barmada, Sami J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269575/
https://ncbi.nlm.nih.gov/pubmed/31714900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130988
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