OPC-167832, a Novel Carbostyril Derivative with Potent Antituberculosis Activity as a DprE1 Inhibitor

There is an urgent need for new, potent antituberculosis (anti-TB) drugs with novel mechanisms of action that can be included in new regimens to shorten the treatment period for TB. After screening a library of carbostyrils, we optimized 3,4-dihydrocarbostyril derivatives and identified OPC-167832 a...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Hariguchi, Norimitsu, Chen, Xiuhao, Hayashi, Yohei, Kawano, Yoshikazu, Fujiwara, Mamoru, Matsuba, Miki, Shimizu, Hiroshi, Ohba, Yoshio, Nakamura, Izuru, Kitamoto, Ryuki, Shinohara, Toshio, Uematsu, Yukitaka, Ishikawa, Shunpei, Itotani, Motohiro, Haraguchi, Yoshikazu, Takemura, Isao, Matsumoto, Makoto
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269503/
https://ncbi.nlm.nih.gov/pubmed/32229496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02020-19
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