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Mutations in ArgS Arginine-tRNA Synthetase Confer Additional Antibiotic Tolerance Protection to Extended-Spectrum-β-Lactamase-Producing Burkholderia thailandensis

Highly conserved PenI-type class A β-lactamase in pathogenic members of Burkholderia species can evolve to extended-spectrum β-lactamase (ESBL), which exhibits hydrolytic activity toward third-generation cephalosporins, while losing its activity toward the original penicillin substrates. We describe...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Yi, Hyojeong, Park, Jongwook, Cho, Kwang-Hwi, Kim, Heenam Stanley
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269490/
https://ncbi.nlm.nih.gov/pubmed/32205346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02252-19
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