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Twelve Positions in a β-Lactamase That Can Expand Its Substrate Spectrum with a Single Amino Acid Substitution

The continuous evolution of β-lactamases resulting in bacterial resistance to β-lactam antibiotics is a major concern in public health, and yet the underlying molecular basis or the pattern of such evolution is largely unknown. We investigated the mechanics of the substrate fspectrum expansion of th...

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Bibliografiske detaljer
Main Authors: Yi, Hyojeong, Cho, Kwang-Hwi, Cho, Yun Sung, Kim, Karan, Nierman, William C., Kim, Heenam Stanley
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358254/
https://ncbi.nlm.nih.gov/pubmed/22629423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037585
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