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Actein Inhibits Tumor Growth and Metastasis in HER2-Positive Breast Tumor Bearing Mice via Suppressing AKT/mTOR and Ras/Raf/MAPK Signaling Pathways

HER2-positive breast cancer accounts for 15–20% in breast cancer and 50% of the metastatic HER2-positive breast cancer patients died of central nervous system progression. The present study investigated the effects of actein (a natural cycloartane triterpene) on cells adhesion, migration, proliferat...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Wu, Xiao-Xiao, Yue, Grace Gar-Lee, Dong, Jin-Run, Lam, Christopher Wai-Kei, Wong, Chun-Kwok, Qiu, Ming-Hua, Lau, Clara Bik-San
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269144/
https://ncbi.nlm.nih.gov/pubmed/32547952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00854
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