Proteolytic and Nonproteolytic Activation Mechanisms Result in Conformationally and Functionally Different Forms of Coagulation Factor XIII A

Factor XIIIA (FXIIIA) is a transglutaminase that crosslinks intra- and extracellular protein substrates. FXIIIA is expressed as an inactive zymogen, and during blood coagulation, it is activated by removal of an activation peptide by the protease thrombin. No such proteolytic FXIIIA activation is kn...

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Bibliographic Details
Published in:FEBS J
Main Authors: Anokhin, Boris A., Dean, William L., Smith, Kerrie A., Flick, Matthew J., Ariëns, Robert A.S., Philippou, Helen, Maurer, Muriel C.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269131/
https://ncbi.nlm.nih.gov/pubmed/31407850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.15040
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