Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg-negative chronic HBV genotype-D infection

Increasing evidences suggest that HBsAg-production varies across HBV-genotypes. HBsAg C-terminus plays a crucial role for HBsAg-secretion. Here, we evaluate HBsAg-levels in different HBV-genotypes in HBeAg-negative chronic infection, the correlation of specific mutations in HBsAg C-terminus with HBs...

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書誌詳細
出版年:Emerg Microbes Infect
主要な著者: Salpini, Romina, Battisti, Arianna, Piermatteo, Lorenzo, Carioti, Luca, Anastasiou, Olympia E., Gill, Upkar S., Di Carlo, Domenico, Colagrossi, Luna, Duca, Leonardo, Bertoli, Ada, La Rosa, Katia Yu, Fabeni, Lavinia, Iuvara, Alessandra, Malagnino, Vincenzo, Cerva, Carlotta, Lichtner, Miriam, Mastroianni, Claudio M., De Sanctis, Giuseppe Maria, Paoloni, Maurizio, Marignani, Massimo, Pasquazzi, Caterina, Iapadre, Nerio, Parruti, Giustino, Vecchiet, Jacopo, Sarmati, Loredana, Andreoni, Massimo, Angelico, Mario, Grelli, Sandro, T. Kennedy, Patrick, Verheyen, Jens, Aquaro, Stefano, Ceccherini-Silberstein, Francesca, Perno, Carlo Federico, Svicher, Valentina
フォーマット: Artigo
言語:Inglês
出版事項: Taylor & Francis 2020
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Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269061/
https://ncbi.nlm.nih.gov/pubmed/32312174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/22221751.2020.1757998
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