Novel HBsAg mutations correlate with hepatocellular carcinoma, hamper HBsAg secretion and promote cell proliferation in vitro

BACKGROUND: An impaired HBsAg-secretion can increase HBV oncogenic-properties. Here, we investigate genetic-determinants in HBsAg correlated with HBV-induced hepatocellular carcinoma (HCC), and their impact on HBsAg-secretion and cell-proliferation. METHODS: This study included 128 chronically HBV-i...

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Vydáno v:Oncotarget
Hlavní autoři: Salpini, Romina, Surdo, Matteo, Warner, Nadia, Cortese, Maria Francesca, Colledge, Danny, Soppe, Sally, Bellocchi, Maria Concetta, Armenia, Daniele, Carioti, Luca, Continenza, Fabio, Carlo, Domenico Di, Saccomandi, Patrizia, Mirabelli, Carmen, Pollicita, Michela, Longo, Roberta, Romano, Sara, Cappiello, Giuseppina, Spanò, Alberto, Trimoulet, Pascale, Fleury, Herve, Vecchiet, Jacopo, Iapadre, Nerio, Barlattani, Angelo, Bertoli, Ada, Mari, Terenzio, Pasquazzi, Caterina, Missale, Gabriele, Sarrecchia, Cesare, Orecchini, Elisa, Michienzi, Alessandro, Andreoni, Massimo, Francioso, Simona, Angelico, Mario, Verheyen, Jens, Ceccherini-Silberstein, Francesca, Locarnini, Stephen, Perno, Carlo Federico, Svicher, Valentina
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362517/
https://ncbi.nlm.nih.gov/pubmed/28152517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14944
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