Novel HBsAg mutations correlate with hepatocellular carcinoma, hamper HBsAg secretion and promote cell proliferation in vitro

BACKGROUND: An impaired HBsAg-secretion can increase HBV oncogenic-properties. Here, we investigate genetic-determinants in HBsAg correlated with HBV-induced hepatocellular carcinoma (HCC), and their impact on HBsAg-secretion and cell-proliferation. METHODS: This study included 128 chronically HBV-i...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Salpini, Romina, Surdo, Matteo, Warner, Nadia, Cortese, Maria Francesca, Colledge, Danny, Soppe, Sally, Bellocchi, Maria Concetta, Armenia, Daniele, Carioti, Luca, Continenza, Fabio, Carlo, Domenico Di, Saccomandi, Patrizia, Mirabelli, Carmen, Pollicita, Michela, Longo, Roberta, Romano, Sara, Cappiello, Giuseppina, Spanò, Alberto, Trimoulet, Pascale, Fleury, Herve, Vecchiet, Jacopo, Iapadre, Nerio, Barlattani, Angelo, Bertoli, Ada, Mari, Terenzio, Pasquazzi, Caterina, Missale, Gabriele, Sarrecchia, Cesare, Orecchini, Elisa, Michienzi, Alessandro, Andreoni, Massimo, Francioso, Simona, Angelico, Mario, Verheyen, Jens, Ceccherini-Silberstein, Francesca, Locarnini, Stephen, Perno, Carlo Federico, Svicher, Valentina
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362517/
https://ncbi.nlm.nih.gov/pubmed/28152517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14944
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