Novel HBsAg mutations correlate with hepatocellular carcinoma, hamper HBsAg secretion and promote cell proliferation in vitro

BACKGROUND: An impaired HBsAg-secretion can increase HBV oncogenic-properties. Here, we investigate genetic-determinants in HBsAg correlated with HBV-induced hepatocellular carcinoma (HCC), and their impact on HBsAg-secretion and cell-proliferation. METHODS: This study included 128 chronically HBV-i...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Salpini, Romina, Surdo, Matteo, Warner, Nadia, Cortese, Maria Francesca, Colledge, Danny, Soppe, Sally, Bellocchi, Maria Concetta, Armenia, Daniele, Carioti, Luca, Continenza, Fabio, Carlo, Domenico Di, Saccomandi, Patrizia, Mirabelli, Carmen, Pollicita, Michela, Longo, Roberta, Romano, Sara, Cappiello, Giuseppina, Spanò, Alberto, Trimoulet, Pascale, Fleury, Herve, Vecchiet, Jacopo, Iapadre, Nerio, Barlattani, Angelo, Bertoli, Ada, Mari, Terenzio, Pasquazzi, Caterina, Missale, Gabriele, Sarrecchia, Cesare, Orecchini, Elisa, Michienzi, Alessandro, Andreoni, Massimo, Francioso, Simona, Angelico, Mario, Verheyen, Jens, Ceccherini-Silberstein, Francesca, Locarnini, Stephen, Perno, Carlo Federico, Svicher, Valentina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
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Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362517/
https://ncbi.nlm.nih.gov/pubmed/28152517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14944
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