Histidine-Rich Glycoprotein Inhibits High-Mobility Group Box-1-Mediated Pathways in Vascular Endothelial Cells through CLEC-1A

High-mobility group box-1 (HMGB1) protein has been postulated to play a pathogenic role in severe sepsis. Histidine-rich glycoprotein (HRG), a 75 kDa plasma protein, was demonstrated to improve the survival rate of septic mice through the regulation of neutrophils and endothelium barrier function. A...

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Publicado en:iScience
Main Authors: Gao, Shangze, Wake, Hidenori, Sakaguchi, Masakiyo, Wang, Dengli, Takahashi, Youhei, Teshigawara, Kiyoshi, Zhong, Hui, Mori, Shuji, Liu, Keyue, Takahashi, Hideo, Nishibori, Masahiro
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7267745/
https://ncbi.nlm.nih.gov/pubmed/32498020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101180
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