Histidine‐rich glycoprotein ameliorates endothelial barrier dysfunction through regulation of NF‐κB and MAPK signal pathway

BACKGROUND AND PURPOSE: Microvascular barrier breakdown is a hallmark of sepsis that is associated with sepsis‐induced multiorgan failure. Histidine‐rich glycoprotein (HRG) is a 75‐kDa plasma protein that was demonstrated to improve the survival of septic mice through regulation of cell shape, spont...

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Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Gao, Shangze, Wake, Hidenori, Gao, Yuan, Wang, Dengli, Mori, Shuji, Liu, Keyue, Teshigawara, Kiyoshi, Takahashi, Hideo, Nishibori, Masahiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609555/
https://ncbi.nlm.nih.gov/pubmed/31093964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14711
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