Histidine-Rich Glycoprotein Prevents Septic Lethality through Regulation of Immunothrombosis and Inflammation

Sepsis is a major cause of death worldwide. We show that a plasma protein histidine-rich glycoprotein (HRG) was decreased significantly in septic mice with cecal ligation and puncture (CLP) and supplementary treatment of septic mice with exogenous HRG improved survival, with strong inhibition of tig...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Wake, Hidenori, Mori, Shuji, Liu, Keyue, Morioka, Yuta, Teshigawara, Kiyoshi, Sakaguchi, Masakiyo, Kuroda, Kosuke, Gao, Yuan, Takahashi, Hideo, Ohtsuka, Aiji, Yoshino, Tadashi, Morimatsu, Hiroshi, Nishibori, Masahiro
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972547/
https://ncbi.nlm.nih.gov/pubmed/27333033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.06.003
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