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Metabolism and disposition of oseltamivir (OS) in rats, determined by immunohistochemistry with monospecific antibody for OS or its active metabolite oseltamivir carboxylate (OC): A possibility of transporters dividing the drugs’ excretion into the bile and kidney

Among any drugs, no comparative pharmacological study on how prodrug and its active metabolite behave in animal bodies is available. Immunohistochemistry (IHCs) using newly prepared two monoclonal antibodies, AOS‐96 and AOC‐160, monospecific for oseltamivir (OS) and its metabolite oseltamivir carbox...

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Dettagli Bibliografici
Pubblicato in:Pharmacol Res Perspect
Autori principali: Fujiwara, Kunio, Yamamoto, Yutaro, Saita, Tetsuya, Matsufuji, Senya
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7266928/
https://ncbi.nlm.nih.gov/pubmed/32489006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.597
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