Endocrine-exocrine signaling drives obesity-associated pancreatic ductal adenocarcinoma

Obesity is a major modifiable risk factor for pancreatic ductal adenocarcinoma (PDAC), yet how and when obesity contributes to PDAC progression is not well understood. Leveraging an autochthonous mouse model, we demonstrate a causal and reversible role for obesity in early PDAC progression, showing...

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Bibliografiske detaljer
Udgivet i:Cell
Main Authors: Chung, Katherine Minjee, Singh, Jaffarguriqbal, Lawres, Lauren, Dorans, Kimberly Judith, Garcia, Cathy, Burkhardt, Daniel B., Robbins, Rebecca, Bhutkar, Arjun, Cardone, Rebecca, Zhao, Xiaojian, Babic, Ana, Vayrynen, Sara A., Costa, Andressa Dias, Nowak, Jonathan A., Chang, Daniel T., Dunne, Richard F., Hezel, Aram F., Koong, Albert C., Wilhelm, Joshua J., Bellin, Melena D., Nylander, Vibe, Gloyn, Anna L., McCarthy, Mark I., Kibbey, Richard G., Krishnaswamy, Smita, Wolpin, Brian M., Jacks, Tyler, Fuchs, Charles S., Muzumdar, Mandar Deepak
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7266008/
https://ncbi.nlm.nih.gov/pubmed/32304665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.03.062
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