Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers

Although it has become increasingly clear that cancers display extensive cellular heterogeneity, the spatial growth dynamics of genetically distinct clones within developing solid tumours remain poorly understood. Here we leverage mosaic analysis with double markers (MADM) to trace subclonal populat...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Muzumdar, Mandar Deepak, Dorans, Kimberly Judith, Chung, Katherine Minjee, Robbins, Rebecca, Tammela, Tuomas, Gocheva, Vasilena, Li, Carman Man-Chung, Jacks, Tyler
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025814/
https://ncbi.nlm.nih.gov/pubmed/27585860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12685
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