Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers

Although it has become increasingly clear that cancers display extensive cellular heterogeneity, the spatial growth dynamics of genetically distinct clones within developing solid tumours remain poorly understood. Here we leverage mosaic analysis with double markers (MADM) to trace subclonal populat...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Muzumdar, Mandar Deepak, Dorans, Kimberly Judith, Chung, Katherine Minjee, Robbins, Rebecca, Tammela, Tuomas, Gocheva, Vasilena, Li, Carman Man-Chung, Jacks, Tyler
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025814/
https://ncbi.nlm.nih.gov/pubmed/27585860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12685
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