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Modeling sporadic loss of heterozygosity in mice by using mosaic analysis with double markers (MADM)
The initiation and progression of many human cancers involve either somatic activation of protooncogenes or inactivation of tumor-suppressor genes (TSGs) in sporadic cells. Although sporadic gain-of-function of protooncogenes has been successfully modeled in mice [e.g., Johnson L, Mercer K, Greenbau...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2007
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1810340/ https://ncbi.nlm.nih.gov/pubmed/17360552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606491104 |
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