Inhibition of GPR35 Preserves Mitochondrial Function After Myocardial Infarction by Targeting Calpain 1/2

Ischemia and anoxia-induced mitochondrial impairment may be a key factor leading to heart injury during myocardial infarction (MI). Calpain 1 and 2 are involved in the MI-induced mitochondria injury. G protein-coupled receptor 35 (GPR35) could be triggered by hypoxia. Whether or not GPR35 regulates...

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Detalhes bibliográficos
Publicado no:J Cardiovasc Pharmacol
Main Authors: Chen, Ken, He, Lei, Li, Yong, Li, Xiuchuan, Qiu, Chenming, Pei, Haifeng, Yang, Dachun
Formato: Artigo
Idioma:Inglês
Publicado em: Journal of Cardiovascular Pharmacology 2020
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7266003/
https://ncbi.nlm.nih.gov/pubmed/32195756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0000000000000819
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