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Virtual docking screening and QSAR studies to explore AKT and mTOR inhibitors acting on PI3K in cancers
The phosphoinositide 3-kinase (PI3K) pathway is an important regulator of cell proliferation and metabolism. PI3K activation initiates a signal transduction cascade, of which the major effectors are the kinases AKT and mTOR. Aberrant activation of the PI3K/AKT/mTOR pathway is frequently observed in...
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| Udgivet i: | Contemp Oncol (Pozn) |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Termedia Publishing House
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7265960/ https://ncbi.nlm.nih.gov/pubmed/32514232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5114/wo.2020.93334 |
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