The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion

The pathophysiological nature of the common ABCG2 gout and hyperuricemia associated variant Q141K (rs2231142) remains undefined. Here, we use a human interventional cohort study (ACTRN12615001302549) to understand the physiological role of ABCG2 and find that participants with the Q141K ABCG2 varian...

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Publicado no:Nat Commun
Main Authors: Hoque, Kazi Mirajul, Dixon, Eryn E., Lewis, Raychel M., Allan, Jordyn, Gamble, Gregory D., Phipps-Green, Amanda J., Halperin Kuhns, Victoria L., Horne, Anne M., Stamp, Lisa K., Merriman, Tony R., Dalbeth, Nicola, Woodward, Owen M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7265540/
https://ncbi.nlm.nih.gov/pubmed/32488095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16525-w
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