Pleiotropic effect of the ABCG2 gene in gout: involvement in serum urate levels and progression from hyperuricemia to gout

BACKGROUND: The ABCG2 Q141K (rs2231142) and rs10011796 variants associate with hyperuricaemia (HU). The effect size of ABCG2 rs2231142 on urate is ~ 60% that of SLC2A9, yet the effect size on gout is greater. We tested the hypothesis that ABCG2 plays a role in the progression from HU to gout by test...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Wrigley, Rebekah, Phipps-Green, Amanda J., Topless, Ruth K., Major, Tanya J., Cadzow, Murray, Riches, Philip, Tausche, Anne-Kathrin, Janssen, Matthijs, Joosten, Leo A. B., Jansen, Tim L., So, Alexander, Harré Hindmarsh, Jennie, Stamp, Lisa K., Dalbeth, Nicola, Merriman, Tony R.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7069001/
https://ncbi.nlm.nih.gov/pubmed/32164793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-020-2136-z
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