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Multistable and dynamic CRISPRi-based synthetic circuits

Gene expression control based on CRISPRi (clustered regularly interspaced short palindromic repeats interference) has emerged as a powerful tool for creating synthetic gene circuits, both in prokaryotes and in eukaryotes; yet, its lack of cooperativity has been pointed out as a potential obstacle fo...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Santos-Moreno, Javier, Tasiudi, Eve, Stelling, Joerg, Schaerli, Yolanda
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7265303/
https://ncbi.nlm.nih.gov/pubmed/32488086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16574-1
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