SIRT5 impairs aggregation and activation of the signaling adaptor MAVS through catalyzing lysine desuccinylation

RLR‐mediated type I IFN production plays a pivotal role in innate antiviral immune responses, where the signaling adaptor MAVS is a critical determinant. Here, we show that MAVS is a physiological substrate of SIRT5. Moreover, MAVS is succinylated upon viral challenge, and SIRT5 catalyzes desuccinyl...

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Publicat a:EMBO J
Autors principals: Liu, Xing, Zhu, Chunchun, Zha, Huangyuan, Tang, Jinhua, Rong, Fangjing, Chen, Xiaoyun, Fan, Sijia, Xu, Chenxi, Du, Juan, Zhu, Junji, Wang, Jing, Ouyang, Gang, Yu, Guangqing, Cai, Xiaolian, Chen, Zhu, Xiao, Wuhan
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7265249/
https://ncbi.nlm.nih.gov/pubmed/32301534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019103285
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