Desuccinylation of pyruvate kinase M2 by SIRT5 contributes to antioxidant response and tumor growth

Tumor cells trends to express high level of pyruvate kinase M2 (PKM2). The inhibition of PKM2 activity is needed for antioxidant response by diverting glucose flux into the pentose phosphate pathway and thus generating sufficient reducing potential. Here we report that PKM2 is succinylated at lysine...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Xiangyun, Ye, Xiaomin, Niu, linping, Gu, Yunhua, Xu, Ziming, Li, Yongfeng, Yu, Zhiwei, Chen, Shun, Lu
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5351684/
https://ncbi.nlm.nih.gov/pubmed/28036303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14346
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